Not all nail fungal testing is created equal.
NGL uses PCR testing + histochemical staining to provide you with targeted therapy to treat your patients and improve clinical outcomes.
“Fungal diseases are often misdiagnosed which can delay appropriate antifungal treatment. Increasingly, fungi are becoming resistant to one or more antifungals. The CDC supports optimizing state-of-the-art lab technology that uses genome sequencing to identify specific mutations associated with antimicrobial resistance.”
-CENTERS FOR DISEASE CONTROL AND PREVENTION (CDC)
ONYCHODYSTROPHY TEST DETAILS
Methodology
DNA (PCR) testing with terbinafine resistance
Histochemical staining (PAS, GMS, FM)
Specimen​
Nail
​Patient Preparation
None
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Submission
Non-fixed dry sample​
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Transport Temperature
Room temperature​
PCR TESTING INCLUDES:
PATHOGENS
Epidermophyton floccosum
Microsporum (adouinii, canis, ferrugineum)
Trichophyton interdigitale/mentagrophytes
Trichophyton rubrum
Trichophyton tonsurans
Trichophyton (verrucosum, violaceum, terrestre)
Alternaria spp.
Aspergillus (fumigatis, flavus)
Curvularia lunata
Fusarium (keratoplasticum, solani)
Malassezia furfur
Scopulariopsis brevicaulis
Scytalidium dimidiatum
Trichosporon asahii
Candida albicans
Candida group (glabrata, krusei, parapsilosis, tropicalis)
Pseudomonas aeruginosa
ANTIBIOTIC RESISTANCE
ACT, FOX, ACC, MOX
GES, PER, VEB, CMY
KPC
OXA-48
erm(A), erm(B), erm(C)
CTX-M
mef(A)
cfr
TEM, SHV, MIR, VEB-1
mecA
qnrA, qnrS, qnrB
tet(B), tet(M), tet(S)
vanA1, vanA2, vanB
dfrA1, dfrA5, sul1, sul2
IMP-16, IMP-7, NDM, VIM
ANTI-FUNGAL
RESISTANCE (terbinafine)
SQLE: Leu393Phe, Phe397Leu, Leu393Ser, Phe397lle, Phe397Va
Clear Lab Interpretations for Complicated Diagnostic Results
ADVANCED REPORTING THAT BLENDS DECADES OF EXPERT INFECTIOUS DISEASE KNOWLEDGE WITH MACHINE-LEARNING ARTIFICIAL INTELLIGENCE
2
ORGANISMS DETECTED
Identifies which organisms are likely pathogens and commonly associated with infection, along with the resistant genes relevant to ensure effective precision guided treatment recommendations.
3
ANTIMICROBIAL RESISTANCE ARKSCORE
TM
Calculates the level of resistance detected. A patient will be less resistant to antibiotic therapy with a lower score.
5
ALLERGIES REPORTED
Removes incompatible treatment options based on a patient’s medication allergies.
6
ADVERSE REACTION ARKSCORE
TM
Ranks antibiotics based on associated risks, current FDA warnings, and other factors. The safer the drug, the lower the score.
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1
INFECTION COMPLEXITY ARKSCORE
TM
Provides a comprehensive view of the challenges presented by the organisms and resistance genes detected in finding an optimal treatment plan. There are fewer therapeutic choices for more complicated infections.
4
TREATMENT RECOMMENDATION
Displays the optimal drug regimen, dosage, duration of therapy, and route of administration. Recommendations are based on source, common pathogens, and resistant genes detected.
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ALTERNATIVE TREATMENT OPTIONS
Each report is tailored for specific clinical scenarios, taking into account alternative treatment and duration options, treatment indications, and special considerations.
